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[A+ ์—ฐ์„ธ๋Œฟ’][2019 1ํ•™๊ธฐ ์ง„ํ–‰] ๋ฏธ์ƒ๋ฌผ๋ฐ์ƒ๋ฌผ๊ณตํ•™๊ธฐ์ดˆ์‹คํ—˜ Lab 9: Representation of Molecule structure ๊ฒฐ๊ณผ๋ ˆํฌํŠธ

7 ํŽ˜์ด์งฟ’
์›Œ๋“œ
์ตœ์ดˆ๋“ฑ๋ก์ผ 2019.08.26 ์ตœ์ข…์ ฟ’์ž‘์ผ 2019.04
7P ๋ฏธ๋้ฉ๋ณด๊ธฐ
[A+ ์—ฐ์„ธ๋Œฟ’][2019 1ํ•™๊ธฐ ์ง„ํ–‰] ๋ฏธ์ƒ๋ฌผ๋ฐ์ƒ๋ฌผ๊ณตํ•™๊ธฐ์ดˆ์‹คํ—˜ Lab 9: Representation of Molecule structure ๊ฒฐ๊ณผ๋ ˆํฌํŠธ
  • ๋ฏธ๋้ฉ๋ณด๊ธฐ

    ์†Œ๊ฐœ

    2019๋…„ 1ํ•™๊ธฐ์— ์ง„ํ–‰๋œ ์ƒ๋ช…๊ณตํ•™๊ณผ ๋ฏธ์ƒ๋ฌผ๋ฐ์ƒ๋ฌผ๊ณตํ•™๊ธฐ์ดˆ์‹คํ—˜ ๊ณผ๋ชฉ์—์„œ ์ตœ์ข… ์„ฑ์  A+๋ฅผ ๋ฐ›์€ ๊ฒฐ๊ณผ๋ ˆํฌํŠธ์ž…๋‹ˆ๋‹ค. ๊ฒฐ๊ณผ๋ ˆํฌํŠธ๊ฐ€ YSCEC์„ ์ด์šฉํ•˜์—ฌ Turnitin ๊ฒ€์ˆ˜๊ณผ์ •์„ ๊ฑฐ์น˜์ง€ ์•Š๊ณ  ๋ฉ”์ผ๊ณผ ํ•˜๋“œ์นดํ”ผ ์ œ์ถœ๋กœ ์ด๋ฃจ์–ด์ง€๊ธฐ ๋•Œ๋ฌธ์— ํ•ด๋‹น ๋ ˆํฌํŠธ ๋‚ด์šฉ์„ ์กฐ๊ธˆ์”ฉ๋งŒ ๋ณ€๊ฒฝํ•˜์—ฌ ์ œ์ถœํ•˜์‹œ๋ฉด ์ˆ˜์›”ํ•˜๊ฒŒ A+๋ฅผ ๋ฐ›์•„๊ฐ€์‹ค ์ˆ˜ ์žˆ์„ ๊ฒƒ์ž…๋‹ˆ๋‹ค. ๊ธ€๊ผด์€ ๋ง‘์€ ๊ณ ๋”•(๋ณธ๋ฌธ) ํ˜น์€ aํƒ€์ดํ‹€๊ณ ๋”•(๋„ค์ด๋ฒ„์—์„œ ๋‹ค์šด๋กœ๋“œ ๊ฐ€๋Šฅ)์œผ๋กœ ์ž‘์„ฑํ•˜์˜€์Šต๋‹ˆ๋‹ค.

    ๋ชฉ์ฐจ

    1. Quiz
    2. Reference

    ๋ณธ๋ๅฉ๋‚ด์šฉ

    Cartesian coordinates system is the most common representation used. It can have a rectilinear 2D (x, y) or 3D (x, y, z) coordinates. For the 3D coordinates the three axes are orthogonal, meaning that they have right angles to each other. Letโ€™s look at the case of cartesian coordinates of the plane, and cartesian coordinates of three-dimensional space.
    Cartesian coordinates in a plane have x-coordinate axis and y-coordinate axis. The origin is where the intersection of the two axes occur, and the points that exist on the plane are written as (x, y). The number x is referred to as the x coordinate of x component, and it represents the distance that is signed from the origin along the x axis. If x is positive the x coordinate will specify the distance to the right of the y axis, and if x is negative the x coordinate will locate on the left side of the y axis. The below model is the point which coordinates (-3, 2). This means that 3 units moved left along the x axis and 2 units moved up the y axis compared to the original point.

    ์ฐธ๊ณ ์ž๋ฃŒ

    ยท โ€œCartesian Coordinatesโ€, Math Insight, Nykamp DQ, Web, May 23rd 2019
    ยท <https://mathinsight.org/cartesian_coordinates>
    ยท โ€œThe Coordinate Planeโ€, Monetery Institute, Web, May 23rd 2019
    ยท <http://www.montereyinstitute.org/courses/DevelopmentalMath/COURSE_TEXT2_RESOURCE/U13_L1_T1_text_final.html>
    ยท โ€œCoordinate System Comparison, Dyamics, Web, May 23rd 2019
    ยท <http://dynref.engr.illinois.edu/rkm.html>
    ยท โ€œCartesian Coordinate System, Portland State University, Web, May 23rd 2019
    ยท <web.cecs.pdx.edu/...479/.../2012-1800.%20Cartesian%20Coordinate%20System.PPT>
    ยท โ€œInternal Coordinate Molecular Dynamics: A Foundation for Multiscale Dynamicsโ€, Nagarajan Vaidehi, Abhinandan Jain, The Journal of Physical Chemistry B, December 2014
    ยท โ€œRecent Trends and Applications of Molecular Modeling in GPCR-Ligand Recognition and Structure-Based Drug Designโ€, Xiaojing Yuan, Yechun Xu, International Journal of Molecular Sciences, July 2018
    ยท โ€œChronic Myeloid Leukemia and the Development of Gleevecโ€, Michael Lill, Medicinenet, June 2018
    ยท โ€œMolecular Modeling: A Powerful Tool for Drug Design and Molecular Dockingโ€, Rama Rao Nadendla, Resonance, May 2004
    ยท โ€œSample Z-matrix inputsโ€, iopenshell, Web, May 23rd 2019
    ยท <http://iopenshell.usc.edu/howto/zmatrix/>
    ยท โ€œExperiment in Microbiology and Biochemical Engineeringโ€, ์ด๋™์šฐ ์™ธ 7๋ช… ์ €, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University
    ยท โ€œComputational Systems Biology Lab. Exercise#1: Representation of Molecular Structureโ€, cslab, Web, May 23rd 2019
    ยท <https://www.csblab.or.kr/BasicExp/23583>
  • ์ž๋ฃŒํ›„๊ธฐ

      Ai ๋ฆฌ๋ทฐ
      ์งฟ’์‹ํŒ๋งค์ž์˜ ์ด ์ž๋ฃŒ๋Š” ๊ณผ์ œ๋ฅผ ์ž‘์„ฑํ•˜๋Š” ๋ฐ ํ•„์š”ํ•œ ์ •๋ณด๋ฅผ ์™„๋ฒฝํ•˜๊ฒŒ ์ถฉ์กฑ์‹œ์ผœ์ฃผ์—ˆ์Šต๋‹ˆ๋‹ค. ๋•๋ถ„์— ๊ณผ์ œ ์ œ์ถœ ๊ธฐํ•œ์„ ๋งž์ถœ ์ˆ˜ ์žˆ์–ด ์ •๋ง ๊ฐ์‚ฌํ–ˆ์Šต๋‹ˆ๋‹ค.
    • ์ž์ฃผ๋ฌป๋Š”์งˆ๋ๅฉ์˜ ๋‹ต๋ณ€์„ ํ™•์ธํ•ด ์ฃผ์„ธ์š”

      ํ•ดํ”ผ์บ ํผ์Šค FAQ ๋”๋ต–๊ธฐ

      ๊ผญ ์•Œ์•„์ฃผ์„ธ์š”

      • ์ž๋ฃŒ์˜ ์ •๋ณด ๋ฐ ๋‚ด์šฉ์˜ ์ง„์‹ค์„ฑ์— ๋Œ€ํ•˜์—ฌ ํ•ดํ”ผ์บ ํผ์Šค๋Š” ๋ณด์ฆํ•˜์ง€ ์•Š์œผ๋ฉฐ, ํ•ด๋‹น ์ •๋ณด ๋ฐ ๊ฒŒ์‹œ๋ฌผ ์ €์ž‘๊ถŒ๊ณผ ๊ธฐํƒ€ ๋ฒ•์  ์ฑ…์ž„์€ ์ž๋ฃŒ ๋“ฑ๋ก์ž์—๊ฒŒ ์žˆ์Šต๋‹ˆ๋‹ค.
        ์ž๋ฃŒ ๋ฐ ๊ฒŒ์‹œ๋ฌผ ๋‚ด์šฉ์˜ ๋ถˆ๋ฒ•์  ์ด์šฉ, ๋ฌด๋‹จ ์ „์žฌโˆ™๋ฐฐํฌ๋Š” ๊ธˆ์ง€๋˜์–ด ์žˆ์Šต๋‹ˆ๋‹ค.
        ์ €์ž‘๊ถŒ์นจํ•ด, ๋ช…์˜ˆํ›ผ์† ๋“ฑ ๋ถ„์Ÿ ์š”์†Œ ๋ฐœ๊ฒฌ ์‹œ ๊ณ ๊ฐ๋น„๋ฐ”์นด์ง€๋…ธ Viva์˜ ์ €์ž‘๊ถŒ์นจํ•ด ์‹ ๊ณ ๋น„๋ฐ”์นด์ง€๋…ธ Viva๋ฅผ ์ด์šฉํ•ด ์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
      • ํ•ดํ”ผ์บ ํผ์Šค๋Š” ๊ตฌ๋งค์ž์™ฟ’ ํŒ๋งค์ž ๋ชจ๋‘๊ฐ€ ๋งŒ์กฑํ•˜๋Š” ์„œ๋น„์Šค๊ฐ€ ๋˜๋„๋ก ๋…ธ๋ ฅํ•˜๊ณ  ์žˆ์œผ๋ฉฐ, ์•„๋ž˜์˜ 4๊ฐ€์ง€ ์ž๋ฃŒํ™˜๋ถˆ ์กฐ๊ฑด์„ ๊ผญ ํ™•์ธํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
        ํŒŒ์ผ์˜ค๋ฅ˜ ์ค‘๋ณต์ž๋ฃŒ ์ €์ž‘๊ถŒ ์—†์Œ ์„ค๋ช…๊ณผ ์‹ค์ œ ๋‚ด์šฉ ๋ถˆ์ผ์น˜
        ํŒŒ์ผ์˜ ๋‹ค์šด๋กœ๋“œ๊ฐ€ ์ œ๋Œ€๋กœ ๋˜์ง€ ์•Š๊ฑฐ๋‚˜ ํŒŒ์ผํ˜•์‹์— ๋งž๋Š” ํ”„๋กœ๊ทธ๋žจ์œผ๋กœ ์ •์ƒ ์ž‘๋™ํ•˜์ง€ ์•Š๋Š” ๊ฒฝ์šฐ ๋‹ค๋ฅธ ์ž๋ฃŒ์™ฟ’ 70% ์ด์ƒ ๋‚ด์šฉ์ด ์ผ์น˜ํ•˜๋Š” ๊ฒฝ์šฐ (์ค‘๋ณต์ž„์„ ํ™•์ธํ•  ์ˆ˜ ์žˆ๋Š” ๊ทผ๊ฑฐ ํ•„์š”ํ•จ) ์ธํ„ฐ๋„ท์˜ ๋‹ค๋ฅธ ์‚ฌ์ดํŠธ, ์—ฐ๊ตฌ๊ธฐ๊ด€, ํ•™๊ป“, ์„œ์  ๋“ฑ์˜ ์ž๋ฃŒ๋ฅผ ๋„์šฉํ•œ ๊ฒฝ์šฐ ์ž๋ฃŒ์˜ ์„ค๋ช…๊ณผ ์‹ค์ œ ์ž๋ฃŒ์˜ ๋‚ด์šฉ์ด ์ผ์น˜ํ•˜์ง€ ์•Š๋Š” ๊ฒฝ์šฐ
    ๋ฌธ์„œ ์ดˆ์•ˆ์„ ์ƒ์„ฑํ•ด์ฃผ๋Š” EasyAI
    ์•ˆ๋…•ํ•˜์„ธ์š”. ํ•ดํ”ผ์บ ํผ์Šค์˜ ๋ฐฉ๋Œ€ํ•œ ์ž๋ฃŒ ์ค‘์—์„œ ์„ ๋ณ„ํ•˜์—ฌ ๋‹น์‹ ๋งŒ์˜ ์ดˆ์•ˆ์„ ๋งŒ๋“ค์–ด์ฃผ๋Š” EasyAI ์ž…๋‹ˆ๋‹ค.
    ์ €๋Š” ์•„๋ž˜์™ฟ’ ๊ฐ™์ด ์ž‘์—…์„ ๋„์™ฟ’๋“œ๋ฆฝ๋‹ˆ๋‹ค.
    - ์ฃผ์ œ๋งŒ ์ž…๋ ฅํ•˜๋ฉด ๋ชฉ์ฐจ๋ถ€ํ„ฐ ๋ณธ๋ๅฉ๋‚ด์šฉ๊นŒ์ง€ ์ž๋™ ์ƒ์„ฑํ•ด ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
    - ์žฅ๋ฌธ์˜ ์ฝ˜ํ…์ธ ๋ฅผ ์‰ฝ๊ณ  ๋น ๋ฅด๊ฒŒ ์ž‘์„ฑํ•ด ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
    - ์Šคํ† ์–ด์—์„œ ๋ฌด๋ฃŒ ์บ์‹œ๋ฅผ ๊ณ„์ •๋ณ„๋กœ 1ํšŒ ๋ฐœ๊ธ‰ ๋ฐ›์„ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ง€๊ธˆ ๋ฐ”๋กœ ์ฒดํ—˜ํ•ด ๋ณด์„ธ์š”!
    ์ด๋Ÿฐ ์ฃผ์ œ๋“ค์„ ์ž…๋ ฅํ•ด ๋ณด์„ธ์š”.
    - ์œ ์•„์—๊ฒŒ ์ ํ•ฉํ•œ ๋ฌธํ•™์ž‘ํ’ˆ์˜ ๊ธฐ์ค€๊ณผ ํŠน์„ฑ
    - ํ•œ๊ตญ์ธ์˜ ๊ฐ€์น˜๊ด€ ์ค‘์—์„œ ์ •์‹ ์  ๊ฐ€์น˜๊ด€์„ ์ด๋ฃจ๋Š” ๊ฒƒ๋“ค์„ ๋ฌธํ™”์  ๋ฌธ๋ฒ•์œผ๋กœ ์ •๋ฆฌํ•˜๊ณ , ํ˜„๋Œ€ํ•œ๊ตญ์‚ฌํšŒ์—์„œ ์ผ์–ด๋‚˜๋Š” ์‚ฌ๊ฑด๊ณผ ์‚ฌ๊ณ ๋ฅผ ๋น„๊ตํ•˜์—ฌ ์ž์‹ ์˜ ์˜๊ฒฌ์œผ๋กœ ๊ธฐ์ˆ ํ•˜์„ธ์š”
    - ์ž‘๋ณ„์ธ์‚ฌ ๋…ํ›„๊ฐ
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