[????]???? ??

(1)????? ?????
��glutamic acid?? ��aspartic acid??
��lysine ?? ��pyruvic acid??
��histidine-serine?? ��??? ??????? ????.
(2)???? ????
???? ???? ???, ???, ???, ??? ?? ??? ?? ?? ???? ??
??? ???? ??? ???? ??? ?? ??, ?? ??? ??? ? ???? ??
?? ??.
(3)??? ? ???
��?????
?????? ???? ?? : ????? ??? ?? ????? ???? ??????? ?? ?? ???? ??, ????? ???? L-glutamic acid?? ??????.
?????? ???? ???? ?? : ????? ???? ????? nitrosoguanidine
(NTG)?? ?? ???(mutagen)? ??? ?? ??? ???(auxotroph)? ??? ???? lysine, valine, alanine?? ???? ??.
?Analog?????? ???? ?? : 5-Methyl tryptophan?? S-aminoethyl-L-cysteine
(AEC) ?? ???? analog? ?? ?? ???? ???? ??? ????? ? analog
(?? ???)? ??? ?? ???? ???? tryptophan ?? lysine ?? ????? ??,????. ????? ?????? ??? ?? ???? ?? ?? ??? ????. ? ??? ???? ??? lysine, threonine, isoleucine, hestidine, arginine ?? ???? ??.
��????? ???? ???? ??
????? ??? ???? ???? ???? ?? ??? ???? ?? ?? ??? ? ???? ?????? ???? ?????? ????? ????. Glycine????? serine? ???? ��-aminobutyric acid? D-threonine? ???? isoleucine? ???? ??? ??????.
��???? ?? ???? ??
????? ??? ????? ??? ????. Aspartase? ?? fumaric acid????
asprtic acid? ??? ????? ??, lysine, tryptophan, cysteine, phenylalanine?? ???? ???? ??. ???? ??? ???? ??? ????? ???? ???? ??? ?????.