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p53-Based Novel Cancer Therapy

(1) Xue, W. et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. (Nature 445: 656-660, 2007)
(2) Ventura, A. et al. Restoration of p53 function leads to tumour regression in vivo. (Nature 445: 661-665, 2007)
(3) Martins, C.P. et al. Modeling the Therapeutic efficacy of p53 restoration in tumors. (Cell 127: 1323-1334, 2006)
?? ?? ???? ?? ??? ??? ?? ???(oncogene)? ????? ??????. ??? ???? ?? ???? ?? ???? ???? ???? ? ? ??? ??? ? ??? ???? ? ?? ???? ??? ? ??. ?? ? ?????? ?? ??? ???? ?? ?? ???? ?? ????? ??? ?????. ? ???? ????? ?? ?? ??? p53? ??? ????? ???? ??? ?? ?? ??? ????? ??? ????? ?? ?? ??? ? ???? ?????.